The tie of the round takes place on Wednesday night at Old Trafford as Premier League giants Manchester United and Liverpool face off in a huge Capital One Cup match.
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For Liverpool fans, the match at Old Trafford marks an important moment in their season as, after getting off to a blistering start in the league, Luis Suarez finally returns to action.
Having sat out 10 games serving a ban for biting, Suarez should come back into the fold at the Theatre of Dreams, and many will wait to see how the Suarez partnership with Daniel Sturridge get on against one of the best defences in the England.
Liverpool will be without centre-back Daniel Agger who is still struggling with a side strain, meaning that Kolo Toure and Martin Srktel should line up at the heart of the Reds backline.
As for Manchester United, after losing 4-1 at rivals Man City last weekend in the league, David Moyes is set to field another team without Robin van Persie in his line-up against the Scousers.
Van Persie is still nursing a groin strain picked up in training last week, and the Dutchman is unlikely to be risked against Liverpool. That should see Danny Welbeck and Wayne Rooney leading the line for the Red Devils, while Shinji Kagawa could get a run out having barely featured at the start of the campaign for Moyes.