Real Madrid travel to 6th place Levante on Sunday (20:30GMT) hoping to bounce back after their midweek 2-2 draw with Borussia Dortmund.
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3rd placed Real Madrid visit Levante with a few injury problems. Gonzalo Higuain has been ruled out for a month and fellow striker Karim Benzema is also a doubt.
Currently sitting eight points behind Barcelona, 3 points is a must for Mourinho in this difficult fixture. In this fixture last season Levante pulled off a shock 1-0 win and the season before they held Madrid to a 0-0.
Jose Callejon will likely lead the line for Real Madrid in a match of great importance. In good form in the league, Madrid will be looking to forget their 2-2 draw at home to Borussia Dortmund in the Champions League.
Levante currently are sitting pretty in sixth. Their defence have conceded just two in their last seven games, one in their last four league games.
The defence will be key if Levante are to get anything from this game. Keeping Cristiano Ronaldo quiet is nigh on impossible.
At the other end former Newcastle United striker Obafemi Martins is their main goal threat. No goals in their last three competitive fixtures is unlikely to have Pepe & Co. quaking in their boots.