After a 4-0 drubbing in Munich, Barcelona return to domestic matters and can wrap up the La Liga title if victory at San Mames is followed by a Real Madrid defeat to local rivals Atletico.
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It has been a struggling campaign for Athletic Bilbao who have not recovered from losing Javi Martinez in the summer as the Spanish midfielder showed against Barcelona at the Allianz Arena.
The contract issues with Fernando Llorente did not help either and Bilbao have hovered near the bottom of La Liga for much of the campaign.
One win in their last five matches sums up a poor campaign and Barcelona smashed Bilbao 5-1 in December.
Tito Vilanova will ring the changes and rest his big stars in the hope of a once-in-a-lifetime turnaround at the Nou Camp next Wednesday.
The likes of Eric Abidal, Cesc Fabregas, Thiago Alcantara and Cristian Tello can all be expected to start whilst Jordi Alba should also feature as he is suspended for the arrival of Bayern. Lionel Messi, who claimed a brace in the first La Liga match, will almost certainly be rested.
Bilbao, roared on by a passionate home crowd, will likely make things difficult for a second string Barcelona but it would be a big boost if the Catalans can secure the title after a trying week.